google-deepmind/alphagenome

The AlphaGenome API provides access to AlphaGenome, Google DeepMind’s unifying model for deciphering the regulatory code within DNA sequences. This repository contains client-side code, examples and documentation to help you use the AlphaGenome API.

AlphaGenome offers multimodal predictions, encompassing diverse functional outputs such as gene expression, splicing patterns, chromatin features, and contact maps (see diagram below). The model analyzes DNA sequences of up to 1 million base pairs in length and can deliver predictions at single base-pair resolution for most outputs. AlphaGenome achieves state-of-the-art performance across a range of genomic prediction benchmarks, including numerous diverse variant effect prediction tasks (detailed in Avsec et al.).

The API is offered free of charge for non-commercial use (subject to the terms of use). Query rates vary based on demand – it is well suited for smaller to medium-scale analyses such as analysing a limited number of genomic regions or variants requiring 1000s of predictions, but is likely not suitable for large scale analyses requiring more than 1 million predictions. Once you obtain your API key, you can easily get started by following our Quick Start Guide, or watching our AlphaGenome 101 tutorial.